Systematic Analysis of Genetic and Pathway Determinants of Eribulin Sensitivity across 100 Human Cancer Cell Lines from the Cancer Cell Line Encyclopedia (CCLE)

Systematic Analysis of Genetic and Pathway Determinants of Eribulin Sensitivity across 100 Human Cancer Cell Lines from the Cancer Cell Line Encyclopedia (CCLE)

Eribulin, a natural product-based microtubule targeting agent with cytotoxic and noncytotoxic mechanisms, is FDA approved for certain patients with advanced breast cancer and liposarcoma. To investigate the feasibility of developing drug-specific predictive biomarkers, we quantified antiproliferativ...

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Bibliographic Details
Main Authors: Pallavi Sachdev, Roy Ronen, Janusz Dutkowski, Bruce A. Littlefield
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
eribulin
paclitaxel
vinorelbine
gene expression
predictive biomarkers
Online Access:https://www.mdpi.com/2072-6694/14/18/4532

Internet

https://www.mdpi.com/2072-6694/14/18/4532

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