The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway

The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway

Highlights Chemical composition of TPRL was identified by UPLC-Q/TOF/MSn in the profile of total ion current. TPRL was initially demostrated the effects of anti-hepatic fibrosis in vitro and in vivo. TPRL ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway.

Bibliographic Details
Main Authors: Guoguo Wan, Zhiwei Chen, Lei Lei, Xiaoyu Geng, Yi Zhang, Congwen Yang, Wenfu Cao, Zheng Pan
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Chinese Medicine
Subjects:
Polyphenolic glycosides
Lamiophlomis rotata
Hepatic fibrosis
Apoptosis
TGF-β/Smad
Online Access:https://doi.org/10.1186/s13020-023-00723-x

Internet

https://doi.org/10.1186/s13020-023-00723-x

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