PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation

PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation

Abstract In human cells BRAF oncogene is invariably expressed as a mix of two coding transcripts: BRAF-ref and BRAF-X1. These two mRNA isoforms, remarkably different in the sequence and length of their 3′UTRs, are potentially involved in distinct post-transcriptional regulatory circuits. Herein, we...

Full description

Bibliographic Details
Main Authors: Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi, Maurizio S. Podda, Serena Mero, Marianna Vitiello, Cinzia Franchin, Mariavittoria Laezza, Laura Comelli, Giorgio Arrigoni, Tiziana Cervelli, Giovanna Del Pozzo, Laura Poliseno
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Hematology & Oncology
Subjects:
Melanoma
BRAF-X1
mRBP
PARP1
MAPK pathway
Vemurafenib
Online Access:https://doi.org/10.1186/s13045-023-01428-2

Internet

https://doi.org/10.1186/s13045-023-01428-2

Similar Items