Therapeutic influence of simvastatin on MCF-7 and MDA-MB-231 breast cancer cells via mitochondrial depletion and improvement in chemosensitivity of cytotoxic drugs

Therapeutic influence of simvastatin on MCF-7 and MDA-MB-231 breast cancer cells via mitochondrial depletion and improvement in chemosensitivity of cytotoxic drugs

Background: Breast cancer is the most commonly diagnosed cancer worldwide with 2.26 million cases in 2020. Cancer heterogeneity is the major challenge before existing therapeutic modalities due to metabolic variability of the cells as Warburg and anti-Warburg both type of metabolic phenotypes has be...

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Bibliographic Details
Main Authors: Versha Tripathi, Pooja Jaiswal, Ruchi Verma, Khageswar Sahu, Shovan Kumar Majumder, Sourabrata Chakraborty, Hem Chandra Jha, Hamendra Singh Parmar
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Advances in Cancer Biology - Metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667394023000242

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http://www.sciencedirect.com/science/article/pii/S2667394023000242

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