Autoinhibition and activation of myosin VI revealed by its cryo-EM structure
Abstract Myosin VI is the only molecular motor that moves towards the minus end along actin filaments. Numerous cellular processes require myosin VI and tight regulations of the motor’s activity. Defects in myosin VI activity are known to cause genetic diseases such as deafness and cardiomyopathy. H...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45424-7 |