Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells

Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells

Microglia-associated inflammation and miRNA dysregulation are key players in Alzheimer’s disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP Swedish SH-SY5Y (SWE) and PSEN1 iPSC-derived neurons and its propagation by the secretome (soluble and exosomal fractions). After m...

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Bibliographic Details
Main Authors: Gonçalo Garcia, Adelaide Fernandes, Frank Stein, Dora Brites
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
neuronal miR-124-3p mimic/inhibitor
IFNγ-primed CHME3 microglia
SH-SY5Y APPSwedish cell
inflammatory gene expression
mir-124-dependent microglia proteomic changes
MMP-2/MMP-9 deactivation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.833066/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.833066/full

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