Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

IntroductionThe U. S. Environmental Protection Agency’s Endocrine Disruptor Screening Program (EDSP) Tier 1 assays are used to screen for potential endocrine system–disrupting chemicals. A model integrating data from 16 high-throughput screening assays to predict estrogen receptor (ER) agonism has b...

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Bibliographic Details
Main Authors: Mark D. Nelms, Todor Antonijevic, Caroline Ring, Danni L. Harris, Ronnie Joe Bever, Scott G. Lynn, David Williams, Grace Chappell, Rebecca Boyles, Susan Borghoff, Stephen W. Edwards, Kristan Markey
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Toxicology
Subjects:
estrogen receptor
new approach methods
NAMs
chemical prioritization
chemical clustering
endocrine disruptor
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2024.1346767/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2024.1346767/full

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