Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint.

Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint.

Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by intravenous administration. However, the underlying toxic effect mechanisms of silica nanoparticles on endothelial cells are still poorly unde...

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Bibliographic Details
Main Authors: Junchao Duan, Yongbo Yu, Yang Li, Yang Yu, Yanbo Li, Xianqing Zhou, Peili Huang, Zhiwei Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3631220?pdf=render

Internet

http://europepmc.org/articles/PMC3631220?pdf=render

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