Interaction with a phage gene underlie costs of a β-lactamase

ABSTRACTThe fitness cost of an antibiotic resistance gene (ARG) can differ across host strains, creating refuges that allow the maintenance of an ARG in the absence of direct selection for its resistance phenotype. Despite the importance of such ARG-host interactions for predicting ARG dynamics, the...

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Bibliographic Details
Main Authors: Huei-Yi Lai, Tim F. Cooper
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.02776-23