Interaction between human leukocyte antigen (HLA-C) and killer cell Ig-like receptors (KIR2DL) inhibits the cytotoxicity of natural killer cells in patients with hepatoblastoma

BackgroundHepatoblastoma (HB) is the most common liver malignancy in childhood with poor prognosis and lack of effective therapeutic targets. Single-cell transcriptome sequencing technology has been widely used in the study of malignant tumors, which can understand the tumor microenvironment and tum...

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Bibliographic Details
Main Authors: Jing-Jie Guo, Yong-Qin Ye, Yi-Di Liu, Wei-Fang Wu, Qian-Qian Mei, Xi-Yun Zhang, Jing Lao, Bin Wang, Jian-Yao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.947729/full