Inhibition of mtDNA-PRRs pathway-mediated sterile inflammation by astragalus polysaccharide protects against transport stress-induced cardiac injury in chicks

Inhibition of mtDNA-PRRs pathway-mediated sterile inflammation by astragalus polysaccharide protects against transport stress-induced cardiac injury in chicks

ABSTRACT: Transport stress (TS) not only weakens poultry performance but also affects animal welfare. Additionally, TS can evoke cardiac damage by triggering sterile inflammation in chicks, but the underlying mechanism is not fully understood. Here, we aimed to elucidate how TS induces sterile infla...

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Bibliographic Details
Main Authors: Jian Chen, Wang-Ye Xu, Yuan Gu, Yi-Xi Tang, Xiang-Wen Xu, Xue-Nan Li, Jin-Long Li
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Poultry Science
Subjects:
animal welfare
chick
mitochondrial stress
NF-κB
cGAS-STING pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0032579124002177

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http://www.sciencedirect.com/science/article/pii/S0032579124002177

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