Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity

Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity

Abstract Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma....

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Bibliographic Details
Main Authors: Shengnan Yu, Ming Yi, Shuang Qin, Kongming Wu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Molecular Cancer
Subjects:
Chimeric antigen receptor
Toxicity
Immunotherapy
Suicide gene
Synthetic notch receptor
Online Access:http://link.springer.com/article/10.1186/s12943-019-1057-4

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http://link.springer.com/article/10.1186/s12943-019-1057-4

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