Identification of a potent antagonist of smoothened in hedgehog signaling

Identification of a potent antagonist of smoothened in hedgehog signaling

Abstract Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics. Given the close link between aberrant Hedgehog signaling and cancers, many small molecular comp...

Full description

Bibliographic Details
Main Authors: Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng, Wei Chen
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cell & Bioscience
Subjects:
0025A
Antagonist
Cancer
Hedgehog signaling
Primary cilia
Smoothened mutation
Online Access:https://doi.org/10.1186/s13578-021-00558-9

Internet

https://doi.org/10.1186/s13578-021-00558-9

Similar Items