EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice.

EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice.

EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). The EBV latency protein, EBNA2, transcriptionally activates the promoters of all latent viral protein-coding genes expressed...

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Bibliographic Details
Main Authors: Chunrong Li, James C Romero-Masters, Shane Huebner, Makoto Ohashi, Mitchell Hayes, Jillian A Bristol, Scott E Nelson, Mark R Eichelberg, Nicholas Van Sciver, Erik A Ranheim, Rona S Scott, Eric C Johannsen, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008590

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https://doi.org/10.1371/journal.ppat.1008590

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