SNX9 Inhibits Cell Proliferation and Cyst Development in Autosomal Dominant Polycystic Kidney Disease via Activation of the Hippo-YAP Signaling Pathway

SNX9 Inhibits Cell Proliferation and Cyst Development in Autosomal Dominant Polycystic Kidney Disease via Activation of the Hippo-YAP Signaling Pathway

Autosomal dominant polycystic kidney disease (ADPKD) is a complex process, involving the alteration of multiple genes and signaling pathways, and the pathogenesis of ADPKD remains largely unknown. Here, we demonstrated the suppressive role of sorting nexin 9 (SNX9) during ADPKD development. Sorting...

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Bibliographic Details
Main Authors: Ai-Wen Shen, Li-Li Fu, Lu Lin, Bo Sun, Dong-Xu Song, Wu-Tao Wang, Yi-Hao Wang, Pei-Ran Yin, Sheng-Qiang Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SNX9: sorting nexin 9
ADPKD: autosomal dominant polycystic kidney disease
signaling mechanism
the Hippo-YAP signaling pathway
Hippo-Yes associated pathway
therapy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00811/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00811/full

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