Unraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: insights into the crucial role of immunosuppressive cells

Unraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: insights into the crucial role of immunosuppressive cells

Abstract The occurrence and progression of tumors can be established through a complex interplay among tumor cells undergoing epithelial-mesenchymal transition (EMT), invasive factors and immune cells. In this study, we employed single-cell RNA sequencing (scRNA-seq) and spatially resolved transcrip...

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Bibliographic Details
Main Authors: Muhong Wang, Chunyu Deng, Cheng Yang, Mingze Yan, Haibo Lu, Yan Zhang, Honghao Liu, Zhekuan Tong, Jiaao Ma, Jiaming Wang, Jiahao Wang, Yuhong Xuan, Haiyue Cheng, Kai Zhao, Jiaqi Zhang, Cuicui Chai, Mingzhe Li, Zhiwei Yu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Single-cell RNA-seq
Spatial transcriptomics
Tumor immune microenvironment
Epithelial-mesenchymal transition (EMT)
Online Access:https://doi.org/10.1186/s12967-023-04600-x

Internet

https://doi.org/10.1186/s12967-023-04600-x

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