Genotoxin-producing Salmonella enterica induces tissue-specific types of DNA damage and DNA damage response outcomes

Genotoxin-producing Salmonella enterica induces tissue-specific types of DNA damage and DNA damage response outcomes

IntroductionTyphoid toxin-expressing Salmonella enterica causes DNA damage in the intestinal mucosa in vivo, activating the DNA damage response (DDR) in the absence of inflammation. To understand whether the tissue microenvironment constrains the infection outcome, we compared the immune response an...

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Bibliographic Details
Main Authors: Maria Lopez Chiloeches, Anna Bergonzini, Océane C. B. Martin, Nicole Bergstein, Saskia F. Erttmann, Kyaw Min Aung, Nelson O. Gekara, Javier F. Avila Cariño, Ioannis S. Pateras, Teresa Frisan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
bacterial genotoxin
DNA damage response
inflammation
tissue specificity
inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270449/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270449/full

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