Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip

Summary Keratin 8 and 18 (K8/K18) are major intermediate filament proteins of liver hepatocytes. They provide mechanical and nonmechanical stability, thereby protecting cells from stress. Hence, K8-null mice are highly sensitive to Fas-mediated liver cell apoptosis. However, the role of c-Flip prote...

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Bibliographic Details
Main Authors: Jongeun Lee, Kwi-Hoon Jang, Hakhyun Kim, Younglan Lim, Sujin Kim, Han-Na Yoon, In Kwon Chung, Jürgen Roth, Nam-On Ku
Format: Article
Language:English
Published: The Company of Biologists 2013-05-01
Series:Biology Open
Subjects:
Keratin
Intermediate filaments
Liver
c-Flip
Apoptosis
NF-κB
SAPK
Online Access:http://bio.biologists.org/content/2/7/695

Internet

http://bio.biologists.org/content/2/7/695

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