A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42‐mediated GSK‐3β/β‐catenin Signaling

A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42‐mediated GSK‐3β/β‐catenin Signaling

Abstract Kidney fibrosis is a common fate of chronic kidney diseases (CKDs), eventually leading to renal dysfunction. Yet, no effective treatment for this pathological process has been achieved. During the bioassay‐guided chemical investigation of the medicinal plant Wikstroemia chamaedaphne, a daph...

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Bibliographic Details
Main Authors: Xinrong Hu, Lu Gan, Ziwen Tang, Ruoni Lin, Zhou Liang, Feng Li, Changjian Zhu, Xu Han, Ruilin Zheng, Jiani Shen, Jing Yu, Ning Luo, Wenxing Peng, Jiaqing Tan, Xiaoyan Li, Jinjin Fan, Qiong Wen, Xin Wang, Jianbo Li, Xunhua Zheng, Qinghua Liu, Jianping Guo, Guo‐Ping Shi, Haiping Mao, Wei Chen, Sheng Yin, Yi Zhou
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
Cdc42
GSK‐3β/β‐catenin
kidney fibrosis
natural small molecules
Online Access:https://doi.org/10.1002/advs.202307850

Internet

https://doi.org/10.1002/advs.202307850

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