Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo

Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo

Abstract Background Tissue environment is critical in determining tumour metabolic vulnerability. However, in vivo drug testing is slow and waiting for tumour growth delay may not be the most appropriate endpoint for metabolic treatments. An in vivo method for measuring energy stress would rapidly d...

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Bibliographic Details
Main Authors: Piotr Dzien, Agata Mackintosh, Gaurav Malviya, Emma Johnson, Dmitry Soloviev, Gavin Brown, Alejandro Huerta Uribe, Colin Nixon, Scott K. Lyons, Oliver Maddocks, Karen Blyth, David Y. Lewis
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cancer & Metabolism
Subjects:
Positron emission tomography
Reporter genes
Metabolic sensor
Energy charge
2-DG
Oligomycin A
Online Access:https://doi.org/10.1186/s40170-023-00314-2

Internet

https://doi.org/10.1186/s40170-023-00314-2

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