Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

<p>Abstract</p> <p>Background</p> <p>Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex. Neuroinflammation is also present, but its role in AD is not...

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Bibliographic Details
Main Authors: Sutinen Elina M, Pirttilä Tuula, Anderson George, Salminen Antero, Ojala Johanna O
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:http://www.jneuroinflammation.com/content/9/1/199