Early life phenobarbital exposure dysregulates the hippocampal transcriptome

Introduction: Phenobarbital (PB) and levetiracetam (LEV) are the first-line therapies for neonates with diagnosed seizures, however, a growing body of evidence shows that these drugs given during critical developmental windows trigger lasting molecular changes in the brain. While the targets and mec...

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Bibliographic Details
Main Authors: Seán Quinlan, Tahiyana Khan, David McFall, Carolina Campos-Rodriguez, Patrick A. Forcelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1340691/full