Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani.

The parasite Leishmania donovani is one of the species causing visceral leishmaniasis in humans, a deadly infection claiming up to 40,000 lives each year. The current drugs for leishmaniasis treatment have severe drawbacks and there is an urgent need to find new anti-leishmanial compounds. However,...

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Bibliographic Details
Main Authors: Lore Baert, Serena Rudy, Mélanie Pellisson, Thierry Doll, Romina Rocchetti, Marcel Kaiser, Pascal Mäser, Matthias Müller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011559&type=printable