Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3-Phosphohydroxy pyruvate (3-PPyr) in the first...

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Bibliographic Details
Main Authors: Ayesha Sadiqa, Azhar Rasul, Mudassir Hassan, Salma Sultana, Farhat Jabeen
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
tumor metabolism
PHGDH
phytochemicals
molecular docking
in silico analyses
Online Access:https://www.mdpi.com/1420-3049/27/18/6108

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https://www.mdpi.com/1420-3049/27/18/6108

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