Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice

Lipoprotein metabolism is an important contributing factor in the development and progression of atherosclerosis. Plasma lipoproteins and their receptors are heavily glycosylated and sialylated, and levels of sialic acids modulate their biological functions. Sialylation is controlled by the activiti...

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Bibliographic Details
Main Authors: Abraham Yang, Gabriel Gyulay, Mark Mitchell, Elizabeth White, Bernardo L. Trigatti, Suleiman A. Igdoura
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520417936