Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization

Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization

ObjectivesOur aim was to investigate the interactive causal effects between gut microbiota and host urate metabolism and explore the underlying mechanism using genetic methods.MethodsWe extracted summary statistics from the abundance of 211 microbiota taxa from the MiBioGen (N =18,340), 205 microbio...

Full description

Bibliographic Details
Main Authors: Tianzhichao Hou, Huajie Dai, Qi Wang, Yanan Hou, Xiaoyun Zhang, Hong Lin, Shuangyuan Wang, Mian Li, Zhiyun Zhao, Jieli Lu, Yu Xu, Yuhong Chen, Yanyun Gu, Jie Zheng, Tiange Wang, Weiqing Wang, Yufang Bi, Guang Ning, Min Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
gout
uric acid
docosahexaenoic acids
mendelian randomization
mediation
gut microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148591/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148591/full

Similar Items