NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions

NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions

Summary: Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2...

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Main Authors: Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico S. Colombo, Enrico Lugli, Emanuela Marcenaro, Eric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
Vδ2 T cells
NKG2A immune checkpoint
hyper-reactivity
immune education
cancer
cancer immune-therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013383

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http://www.sciencedirect.com/science/article/pii/S2211124721013383

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