Recent advances in understanding the regulation of metalloproteinases [version 1; referees: 2 approved]

Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are responsible for the irreversible degradation of articular cartilage collagen. Although direct inhibition of MMPs fell ou...

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Bibliographic Details
Main Authors: David A. Young, Matt J. Barter, David J. Wilkinson
Format: Article
Language:English
Published: F1000 Research Ltd 2019-02-01
Series:F1000Research
Online Access:https://f1000research.com/articles/8-195/v1