Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD

Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD

Psychostimulants show therapeutic efficacy in the treatment of attention-deficit hyperactivity disorder (ADHD). It is generally assumed that they ameliorate ADHD symptoms via interfering with monoaminergic signaling. We combined behavioral pharmacology, neurochemistry and molecular analyses to ident...

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Bibliographic Details
Main Authors: Yi-Chun eYen, Nils C. Gassen, Andreas eZellner, Theo eRein, Rainer eLandgraf, Carsten T. Wotjak, Elmira eAnderzhanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Amphetamine
Dopamine
Prefrontal Cortex
ADHD
mouse models
NMDA receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00067/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00067/full

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