Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD

Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD

Psychostimulants show therapeutic efficacy in the treatment of attention-deficit hyperactivity disorder (ADHD). It is generally assumed that they ameliorate ADHD symptoms via interfering with monoaminergic signaling. We combined behavioral pharmacology, neurochemistry and molecular analyses to ident...

Full description

Bibliographic Details
Main Authors: Yi-Chun eYen, Nils C. Gassen, Andreas eZellner, Theo eRein, Rainer eLandgraf, Carsten T. Wotjak, Elmira eAnderzhanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Amphetamine
Dopamine
Prefrontal Cortex
ADHD
mouse models
NMDA receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00067/full

Similar Items

Similar Items