Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

Objective: The human cluster of differentiation (CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer (NK) cells targeting hematologic malignancies (HMs). Methods: We implemented a sti...

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Bibliographic Details
Main Authors: Shuangcheng Li, Tianci Wang, Xinghui Xiao, Xiaodong Zheng, Haoyu Sun, Rui Sun, Hongdi Ma, Zhigang Tian, Xiaohu Zheng
Format: Article
Language:English
Published: China Anti-Cancer Association 2024-04-01
Series:Cancer Biology & Medicine
Subjects:
nk cell
cd300a
phosphatidylserine
immune checkpoint
hematologic malignancy
Online Access:https://www.cancerbiomed.org/content/21/4/331

Internet

https://www.cancerbiomed.org/content/21/4/331

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