Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice

Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice

Abstract The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been linked to hearing impairment and retinal degeneration in humans and mice. To understand the function of the Fscn...

Full description

Bibliographic Details
Main Authors: Rongrong Liu, Wenjing Shang, Yingying Liu, Yi Xie, Jun Luan, Ting Zhang, Ying Ma, Zengxian Wang, Yan Sun, Xicheng Song, Fengchan Han
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01851-5

Internet

https://doi.org/10.1038/s41420-024-01851-5

Similar Items