Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

Abstract This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH...

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Bibliographic Details
Main Authors: RAQUEL T. MENEZES, THAÍS C. PEREIRA, JULIANA C. JUNQUEIRA, LUCIANE D. OLIVEIRA, LILIANA SCORZONI
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2022-05-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Cryptococcus neoformans
capsule
fluconazole
duloxetine hydrochloride
synergistic combination
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300902&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300902&lng=en&tlng=en

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