Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS

Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS

Background: Enzymes of tricarboxylic acid (TCA) have recently been recognized as tumor suppressors. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) cause pheochromocytomas and paragangliomas (PCCs/PGLs) and predispose patients to malignant disease with poor prognosis. Methods: Using t...

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Bibliographic Details
Main Authors: Mouna Tabebi, Ravi Kumar Dutta, Camilla Skoglund, Peter Söderkvist, Oliver Gimm
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
SDHB
PCCs/PGLs
hPheo1
OXPHOS
glutamine
GLUD1
Online Access:https://www.mdpi.com/1422-0067/23/1/560

Internet

https://www.mdpi.com/1422-0067/23/1/560

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