Deletion of Slc9a1 in Cx3cr1 + cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk

Deletion of Slc9a1 in Cx3cr1 + cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk

Abstract Microglial Na/H exchanger-1 (NHE1) protein, encoded by Slc9a1, plays a role in white matter demyelination of ischemic stroke brains. To explore underlying mechanisms, we conducted single cell RNA-seq transcriptome analysis in conditional Slc9a1 knockout (cKO) and wild-type (WT) mouse white...

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Bibliographic Details
Main Authors: Shanshan Song, Helena Oft, Shamseldin Metwally, Satya Paruchuri, John Bielanin, Victoria Fiesler, Chaim Sneiderman, Gary Kohanbash, Dandan Sun
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Na+/H+ exchanger isoform-1 (NHE1)
Oligodendrocytes
Single cell RNAseq
Stroke
White matter myelination
Online Access:https://doi.org/10.1186/s12974-024-03065-z

Internet

https://doi.org/10.1186/s12974-024-03065-z

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