SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers

SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers

Altered mitochondrial DNA (mtDNA) occurs in neurodegenerative disorders like Alzheimer's disease (AD); how mtDNA synthesis is linked to neurodegeneration is poorly understood. We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nut...

Full description

Bibliographic Details
Main Authors: Andrés Norambuena, Xuehan Sun, Horst Wallrabe, Ruofan Cao, Naidi Sun, Evelyn Pardo, Nutan Shivange, Dora Bigler Wang, Lisa A. Post, Heather A. Ferris, Song Hu, Ammasi Periasamy, George S. Bloom
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Insulin
Amino acids
mTOR
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001292

Internet

http://www.sciencedirect.com/science/article/pii/S0969996122001292

Similar Items