Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

During Mycobacterium tuberculosis (Mtb) infection, the virulence factor PtpA belonging to the protein tyrosine phosphatase family is delivered into the cytosol of the macrophage. PtpA interacts with numerous eukaryotic proteins modulating phagosome maturation, innate immune response, apoptosis, and...

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Bibliographic Details
Main Authors: Mariana Margenat, Gabriela Betancour, Vivian Irving, Alicia Costábile, Tania García-Cedrés, María Magdalena Portela, Federico Carrión, Fernando E. Herrera, Andrea Villarino
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
tyrosine phosphatase
PtpA
human mitochondrial trifunctional protein
TFP
ECHA
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1095060/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1095060/full

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