Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

During Mycobacterium tuberculosis (Mtb) infection, the virulence factor PtpA belonging to the protein tyrosine phosphatase family is delivered into the cytosol of the macrophage. PtpA interacts with numerous eukaryotic proteins modulating phagosome maturation, innate immune response, apoptosis, and...

Full description

Bibliographic Details
Main Authors:	Mariana Margenat, Gabriela Betancour, Vivian Irving, Alicia Costábile, Tania García-Cedrés, María Magdalena Portela, Federico Carrión, Fernando E. Herrera, Andrea Villarino
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Cellular and Infection Microbiology
Subjects:	Mycobacterium tuberculosis tyrosine phosphatase PtpA human mitochondrial trifunctional protein TFP ECHA
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1095060/full

Similar Items

The secreted tyrosine phosphatase PtpA promotes Staphylococcus aureus survival in RAW 264.7 macrophages through decrease of the SUMOylation host response
by: Nadhuma Youssouf, et al.
Published: (2023-12-01)

Vanadium Compounds as PTP Inhibitors
by: Elsa Irving, et al.
Published: (2017-12-01)

Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling
by: Claudia Penafuerte, et al.
Published: (2017-06-01)

PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case–Control Study
by: Bo M, et al.
Published: (2019-12-01)

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis
by: James Adams, et al.
Published: (2021-11-01)

A fetus with mitochondrial trifunctional protein deficiency: Elevation of 3-OH-acylcarnitines in amniotic fluid functionally assured the genetic diagnosis
by: Ryosuke Bo, et al.
Published: (2016-03-01)

Features of nanomodifiers synthesis based on trifunctional oxyphenyls for mineral suspensions
by: Shapovalov Nikolay Afanasyevich, et al.
Published: (2016-10-01)

Biochemical, Enzymatic, and Computational Characterization of Recurrent Somatic Mutations of the Human Protein Tyrosine Phosphatase PTP1B in Primary Mediastinal B Cell Lymphoma
by: Rongxing Liu, et al.
Published: (2022-06-01)

Green Tea Catechins Induce Inhibition of PTP1B Phosphatase in Breast Cancer Cells with Potent Anti-Cancer Properties: In Vitro Assay, Molecular Docking, and Dynamics Studies
by: Alicja Kuban-Jankowska, et al.
Published: (2020-11-01)

Structure and catalytic mechanism of human protein tyrosine phosphatome
by: Seung Jun Kim
Published: (2012-12-01)

Construction of a trifunctional cellulase and expression in Saccharomyces cerevisiae using a fusion protein
by: Zi-Lu Liu, et al.
Published: (2018-07-01)

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2
by: Kostrzewa T, et al.
Published: (2018-12-01)

Synthesis, In Vitro, and Computational Studies of PTP1B Phosphatase Inhibitors Based on Oxovanadium(IV) and Dioxovanadium(V) Complexes
by: Tomasz Kostrzewa, et al.
Published: (2022-06-01)

Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(<i>1H</i>)-Ones
by: Kira V. Derkach, et al.
Published: (2023-02-01)

Synthesis and Characterization of a Trifunctional Photoinitiator Based on Two Commercial Photoinitiators with α-Hydroxyl Ketone Structure
by: Rong Zhong, et al.
Published: (2021-09-01)

Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP
by: Luis Alberto Perez-Quintero, et al.
Published: (2024-04-01)

PTP4A3 (PRL-3) expression correlate with lymphatic metastases in gastric cancer
by: Anna Pryczynicz, et al.
Published: (2010-04-01)

Inhibitory potential of polyhydroxylated fullerenes against protein tyrosine phosphatase 1B
by: O. L. Kobzar, et al.
Published: (2015-08-01)

ALA induces stomatal opening through regulation among PTPA, PP2AC, and SnRK2.6
by: Zheng Chen, et al.
Published: (2023-08-01)

The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing
by: María Landínez-Macías, et al.
Published: (2021-09-01)

Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model
by: Ruf Peter, et al.
Published: (2012-11-01)

Enantiodivergent synthesis of tricyclic chromans: Remote nucleophilic groups switch selectivity in catalytic asymmetric cascade reactions of trifunctional substrates
by: Zhongwen Sun, et al.
Published: (2021-05-01)

Shikonin and Juglone Inhibit <i>Mycobacterium tuberculosis</i> Low-Molecular-Weight Protein Tyrosine Phosphatase a (Mt-PTPa)
by: Abdulhakeem O. Sulyman, et al.
Published: (2023-09-01)

Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation
by: Tomasz Kostrzewa, et al.
Published: (2021-09-01)

Informaciia apie ECHA konferenciją
by: D. Grabauskaitė
Published: (2015-12-01)

Pd nanocluster-decorated CoFe composite supported on nitrogen carbon nanotubes as a high-performance trifunctional electrocatalyst
by: Revanasiddappa Manjunatha, et al.
Published: (2022-10-01)

Charcot–Marie–Tooth Disease With Episodic Rhabdomyolysis Due to Two Novel Mutations in the β Subunit of Mitochondrial Trifunctional Protein and Effective Response to Modified Diet Therapy
by: Yuqing Guan, et al.
Published: (2021-10-01)

Pengembangan Media ECHA (Elaboration, Cover Song, Historycal Content, Audio Visual) Berbasis Vlog Dalam Pembelajaran Sejarah
by: Eka Dian Susanti, et al.
Published: (2020-03-01)

Detection of Tumor-Specific PTPmu in Gynecological Cancer and Patient Derived Xenografts
by: Jason Vincent, et al.
Published: (2021-01-01)

Mitochondrial trifunctional protein deficiency due to HADHB gene mutation in a Chinese family
by: Xiaona Fu, et al.
Published: (2015-12-01)

Protein Tyrosine Phosphatases: Mechanisms in Cancer
by: Vignesh Sivaganesh, et al.
Published: (2021-11-01)

Curing behavior and thermal properties of trifunctional epoxy resin cured by 4, 4’-diaminodiphenyl sulfone
Published: (2009-08-01)

Reversible sensory neuropathy in mitochondrial trifunctional protein deficiency
by: Sarah Catharina Grünert, et al.
Published: (2022-05-01)

The pro-metastasis tyrosine phosphatase, PRL-3 (<it>PTP4A3</it>), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia
by: Zhou Jianbiao, et al.
Published: (2012-09-01)

Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch)
by: Zhenghong Guo, et al.
Published: (2015-04-01)

PTP61F Mediates Cell Competition and Mitigates Tumorigenesis
by: John E. La Marca, et al.
Published: (2021-11-01)

Potential of the Trifunctional Bispecific Antibody Surek Depends on Dendritic Cells: Rationale for a New Approach of Tumor Immunotherapy
by: Nina Eissler, et al.
Published: (2013-03-01)

Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B
by: Haibing He, et al.
Published: (2016-12-01)

Comparison of Hybrid Blends for Solar Cell Application
by: Maria C. Lechmann, et al.
Published: (2010-03-01)

On the Inhibitability of Natural Products Isolated from <i>Tetradium ruticarpum</i> towards Tyrosine Phosphatase 1B (PTP1B) and α-Glucosidase (3W37): An In Vitro and In Silico Study
by: Dao-Cuong To, et al.
Published: (2021-06-01)