Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment

Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment

IntroductionSurvival rates of the childhood cancer patients are improving, however cancer treatments such as chemotherapy may lead to infertility due to loss of the primordial follicle (PMF) reserve. Doxorubicin (DXR) is a gonadotoxic chemotherapy agent commonly used in childhood cancers. Anti-Mülle...

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Bibliographic Details
Main Authors: Xi Wei, Briet D. Bjarkadottir, Devi Nadjaja, Sairah Sheikh, Muhammad Fatum, Sheila Lane, Suzannah A. Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
anti-Müllerian hormone
doxorubicin
fertility preservation
primordial follicles
ovarian tissue
human ovarian xenograft
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1449156/full

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https://www.frontiersin.org/articles/10.3389/fcell.2024.1449156/full

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