Silencing IQGAP1 alleviates hepatic fibrogenesis via blocking bone marrow mesenchymal stromal cell recruitment to fibrotic liver

Silencing IQGAP1 alleviates hepatic fibrogenesis via blocking bone marrow mesenchymal stromal cell recruitment to fibrotic liver

IQ motif-containing guanosine triphosphatase (GTPase)-activating protein 1 (IQGAP1) is a cytosolic scaffolding protein involved in cell migration. Our previous studies suggest sphingosine 1-phosphate (S1P) triggers bone marrow (BM) mesenchymal stromal cells (BMSCs) to damaged liver, thereby promotin...

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Bibliographic Details
Main Authors: Yuehan Ma, Na Chang, Yuran Liu, Fuquan Liu, Chengbin Dong, Lei Hou, Changbo Qi, Lin Yang, Liying Li
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
IQGAP1
sphingosine 1-phosphate receptor 3
bone marrow mesenchymal stromal cells
migration
liver fibrosis
Cdc42
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121003231

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http://www.sciencedirect.com/science/article/pii/S2162253121003231

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