Chronic intermittent oxygen deprivation alters hippocampal cholinergic and glutamatergic system via oxido-inflammatory burden and HIF-1a/Bcl-2 activity in hypothyroid mice: Ameliorative role of Ginkgo biloba supplement

Chronic intermittent oxygen deprivation alters hippocampal cholinergic and glutamatergic system via oxido-inflammatory burden and HIF-1a/Bcl-2 activity in hypothyroid mice: Ameliorative role of Ginkgo biloba supplement

Background: Several investigations in recent years have reported a relationship between hypothyroidism or ischemia and central nervous system (CNS) beginning from fetal to adult life, but the effect of ischemia and hypothyroidism comorbidity on CNS and whether phytotherapeutic approach would attenua...

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Bibliographic Details
Main Authors: Olusegun G. Adebayo, Cletus Ikechukwu Otene, Modo U. Emmanuel, Favour C. Onwuka, Wadioni Aduema, Benneth Ben-Azu, Gospel Nwikue, Jerome Ndudi. Asiwe, Amalachukwu Okwukwe Ike, Iheanyichukwu Wopara, Noah A. Omeiza, Jude Ijuo Abeje, Samuel A. Onasanwo
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Phytomedicine Plus
Subjects:
Ginkgo biloba
Neuroinflammation
Hif-1α
Hippocampus
Excitotoxicity
Ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031323000477

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http://www.sciencedirect.com/science/article/pii/S2667031323000477

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