TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway

TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway

Abstract Background Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for the placentation and establishment of a successful pregnancy. Insufficient EVT cell invasion leads to the development of preeclampsia (PE) which is a leading cause of maternal and perinatal mor...

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Bibliographic Details
Main Authors: Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng, Ying-Pu Sun
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Reproductive Biology and Endocrinology
Subjects:
TGF-β1
Kisspeptin
KISS1
Trophoblast cells
Invasion
Online Access:https://doi.org/10.1186/s12958-022-00902-9

Internet

https://doi.org/10.1186/s12958-022-00902-9

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