Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Abstract Background Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in the TSC1 or TSC2 genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric disorders (TAND) including autism spectrum disorder...

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Bibliographic Details
Main Authors: Inci S. Aksoylu, Pauline Martin, Francis Robert, Krzysztof J. Szkop, Nicholas E. Redmond, Srirupa Bhattacharyya, Jennifer Wang, Shan Chen, Roberta L. Beauchamp, Irene Nobeli, Jerry Pelletier, Ola Larsson, Vijaya Ramesh
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Autism
Subjects:
Tuberous sclerosis complex
TSC1
Neural progenitor cells
Translatome
Polysome profiling
Autism spectrum disorder
Online Access:https://doi.org/10.1186/s13229-023-00572-3

Internet

https://doi.org/10.1186/s13229-023-00572-3

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