Coenzyme Q10 Supplementation Increases Removal of the <i>ATXN3</i> Polyglutamine Repeat, Reducing Cerebellar Degeneration and Improving Motor Dysfunction in Murine Spinocerebellar Ataxia Type 3

Coenzyme Q10 Supplementation Increases Removal of the <i>ATXN3</i> Polyglutamine Repeat, Reducing Cerebellar Degeneration and Improving Motor Dysfunction in Murine Spinocerebellar Ataxia Type 3

Coenzyme Q10 (CoQ10), a well-known antioxidant, has been explored as a treatment in several neurodegenerative diseases, but its utility in spinocerebellar ataxia type 3 (SCA3) has not been explored. Herein, the protective effect of CoQ10 was examined using a transgenic mouse model of SCA3 onset. The...

Full description

Bibliographic Details
Main Authors: Yu-Ling Wu, Jui-Chih Chang, Hai-Lun Sun, Wen-Ling Cheng, Yu-Pei Yen, Yong-Shiou Lin, Yi-Chun Chao, Ko-Hung Liu, Ching-Shan Huang, Kai-Li Liu, Chin-San Liu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Nutrients
Subjects:
coenzyme Q10
spinocerebellar ataxia type 3
locomotor functions
Purkinje cells
muscle atrophy
Online Access:https://www.mdpi.com/2072-6643/14/17/3593

Internet

https://www.mdpi.com/2072-6643/14/17/3593

Similar Items