Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies

Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies

Abstract Ex vivo cellular system that accurately replicates sickle cell disease and β-thalassemia characteristics is a highly sought-after goal in the field of erythroid biology. In this study, we present the generation of erythroid progenitor lines with sickle cell disease and β-thalassemia mutatio...

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Main Authors: Pragya Gupta, Sangam Giri Goswami, Geeta Kumari, Vinodh Saravanakumar, Nupur Bhargava, Akhila Balakrishna Rai, Praveen Singh, Rahul C. Bhoyar, V. R. Arvinden, Padma Gunda, Suman Jain, Vanya Kadla Narayana, Sayali C. Deolankar, T. S. Keshava Prasad, Vivek T. Natarajan, Vinod Scaria, Shailja Singh, Sivaprakash Ramalingam
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46036-x

Internet

https://doi.org/10.1038/s41467-024-46036-x

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