Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms

Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms

Abstract Pseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation of mucus in the peritoneal cavity. The only effective treatment is aggressive surgery, aimed at removing all visible tumors. However, a high percentage of patients relapse, with subsequent progression and...

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Bibliographic Details
Main Authors: Mari C. Vázquez-Borrego, Melissa Granados-Rodríguez, Florina I. Bura, Ana Martínez-López, Blanca Rufián-Andújar, Francisca Valenzuela-Molina, Lidia Rodríguez-Ortiz, Sergio Haro-Yuste, Ana Moreno-Serrano, Rosa Ortega-Salas, Rafael Pineda-Reyes, Carmen Michán, José Alhama, Antonio Romero-Ruiz, Álvaro Arjona-Sánchez
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Experimental Hematology & Oncology
Subjects:
Cancer
Pseudomyxoma Peritonei
Mucin
KRAS
MRTX1133
Online Access:https://doi.org/10.1186/s40164-023-00465-4

Internet

https://doi.org/10.1186/s40164-023-00465-4

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