Pharmaceutical/Clinical Strategies in the Treatment of Acute Promyelocytic Leukemia: All-Trans Retinoic Acid Encapsulation by Spray-Drying Technology as an Innovative Approach–Comprehensive Overview

Pharmaceutical/Clinical Strategies in the Treatment of Acute Promyelocytic Leukemia: All-Trans Retinoic Acid Encapsulation by Spray-Drying Technology as an Innovative Approach–Comprehensive Overview

Acute promyelocytic leukemia (APL) is phenotypically characterized by the accumulation of dysplastic promyelocytes, resulting from a cytogenetic condition due to the balanced chromosomal translocation t(15;17)(q22;q21). Current first-line treatment of APL includes all-trans retinoic acid (all-trans...

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Bibliographic Details
Main Authors: Antónia Gonçalves, Fernando Rocha, Berta N. Estevinho
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
acute promyelocytic leukemia
all-trans retinoic acid
carrier-based delivery systems
encapsulation technology
promyelocytic gene
retinoic acid receptor α
Online Access:https://www.mdpi.com/1424-8247/16/2/180

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https://www.mdpi.com/1424-8247/16/2/180

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