Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice

Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice

The damaging effects of ionizing radiation (IR) on bone mass are well-documented in mice and humans and are most likely due to increased osteoclast number and function. However, the mechanisms leading to inappropriate increases in osteoclastic bone resorption are only partially understood. Here, we...

Full description

Bibliographic Details
Main Authors: Kimberly K. Richardson, Wen Ling, Kimberly Krager, Qiang Fu, Stephanie D. Byrum, Rupak Pathak, Nukhet Aykin-Burns, Ha-Neui Kim
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
ionizing radiation
bone loss
bone resorption
osteoclast
mitochondria
Sirtuin-3
Online Access:https://www.mdpi.com/1422-0067/23/2/675

Internet

https://www.mdpi.com/1422-0067/23/2/675

Similar Items