Protective Effects of Kirenol against Lipopolysaccharide-Induced Acute Lung Injury through the Modulation of the Proinflammatory NFκB Pathway and the AMPK2-/Nrf2-Mediated HO-1/AOE Pathway

Protective Effects of Kirenol against Lipopolysaccharide-Induced Acute Lung Injury through the Modulation of the Proinflammatory NFκB Pathway and the AMPK2-/Nrf2-Mediated HO-1/AOE Pathway

Acute lung injury (ALI) is an acute and life-threatening inflammatory disease of the lung parenchyma that is associated with high mortality worldwide. No therapeutic strategies have been developed for the mitigation of the proinflammatory response that characterizes ALI. Kirenol has anti-inflammator...

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Bibliographic Details
Main Authors: Frank Cheau-Feng Lin, Shiuan-Shinn Lee, Yi-Ching Li, Yung-Chuan Ho, Wen-Ying Chen, Chun-Jung Chen, Min-Wei Lee, Kun-Lin Yeh, Stella Chin-Shaw Tsai, Yu-Hsiang Kuan
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
lipopolysaccharide
acute lung injury
kirenol
NF-κB pathway
AMPK2/Nrf2-mediated HO-1
AOE pathway
Online Access:https://www.mdpi.com/2076-3921/10/2/204

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https://www.mdpi.com/2076-3921/10/2/204

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