PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy

PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy

ABSTRACT Emerging coronaviruses (CoVs) can cause severe diseases in humans and animals, and, as of yet, none of the currently available broad-spectrum drugs or vaccines can effectively control these diseases. Host antiviral proteins play an important role in inhibiting viral proliferation. One of th...

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Bibliographic Details
Main Authors: Yajuan Jiao, Ning Kong, Hua Wang, Dage Sun, Sujie Dong, Xiaoyong Chen, Hao Zheng, Wu Tong, Hai Yu, Lingxue Yu, Yaowei Huang, Huan Wang, Baokun Sui, Ling Zhao, Ying Liao, Wen Zhang, Guangzhi Tong, Tongling Shan
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Series:Microbiology Spectrum
Subjects:
N protein
PABPC4
SP1
coronaviruses
selective autophagy
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00908-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00908-21

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